Gloria Pryhuber, MD

I am a physician-scientist with more than 30 years as an principal investigator in translational and basic science of lung injury and neonatal immunology, I foster active collaborations of investigators and clinicians in neonatology, pulmonology, infectious disease, obstetrics/perinatology, immunology, microbiology, pathology, molecular biology and genomics, aging effects (from neonate to elderly adult) on function and lung disease. My broad goal is to promote collaborative research to reduce respiratory mortality and morbidity in children and adults. In addition to managing several observational studies in neonatology, including the NIH multicenter Environmental Influences on Child Health Outcomes (ECHO) program, I maintain a basic science laboratory, serve as PI for the Lung Development Molecular Atlas Program (LungMAP) Human Tissue Core (HTC) BioRepository for INvestigation of Diseases of the Lung (BRINDL) now in our 11th year, and as Contact PI for the lung component of the NIH Human Biomolecular Atlas Program (HuBMAP - Lung). As the LungMAP HTC, in partnership with the UNOS national transplant network, provide an extensive and deeply annotated repository of transplant-quality, research-authorized tissues including trachea and lung tissue, peripheral blood mononuclear cells (PBMC), lymph node, spleen and thymus from over 470 donors, newborn to elderly. As such, we provide multiple research centers with opportunities to explore the developing human respiratory tract and immune system in an unusually holistic manner. See LungMAP.net, HuBMAP and LGEA web portals for the work of my laboratory and our collaborators using these samples to generate and make publicly available reference sc/snRNAseq and spatial transcriptomic and proteomic, highly multi-plexed immunofluorescence (phenocycler), cleared section multiphoton and confocal microscopy, and flow cytometry data and in vitro culture techniques. Over 70 publications identify use of the BRINDL repository tissues and infrastructure. The BRINDL repository is approved by the University of Rochester Institutional Review Board as non-human subjects research as we have no access to the donors nor to their identifiers.